Autoimmunity

While acute inflammation in response to infection or tissue injury represents a physiological reaction with purpose to restore homeostasis, this process can at occasions develop into chronic and damaging conditions. In addition to persistent infections this also happens in conditions such as asthma and allergies, autoimmune diseases and in the more rare conditions of autoinflammation. The main theme of the lab is to understand the regulation of chronic inflammation and fibrosis with a focus on these processes associated with autoimmune disorders. By applying a multifaceted approach including cell and molecular analyses together with in vivo modeling and state-of-the-art intravital imaging we aim to elucidate the earliest events in the development of autoimmune insulitis and the therapeutic potential of manipulating these cellular and molecular events.