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Basal Ganglia Pathophysiology

Faculty of Medicine / Department of Experimental Medical Science
Website: http://www.med.lu.se/english/expmed/research/basal_ganglia_pathophysiology

Visiting address: Sölvegatan 19, BMC A13, 221 84 Lund

Service point: 66

Basal Ganglia Pathophysiology's profile in Lund University Research portal

Description

The basal ganglia are a group of interconnected brain nuclei involved in action control. Loss or dysfunction of neurons within the basal ganglia cause some typical motor symptoms, such as poverty of movement (akinesia) or abnormal involuntary movements (dyskinesia). Parkinson´s disease (PD; prevalence ~ 1% in the population over 55 years of age) is the most common neurodegenerative disease affecting the basal ganglia. The typical lesion in PD consists in a loss of dopamine neurons that are located in the substantia nigra. Pharmacological dopamine replacement with L-DOPA remains the most effective treatment for PD. However, this treatment causes severe long-term complications, such as dyskinesia (abnormal involuntary movements). Novel treatment strategies for PD, such as intracerebral neural transplants, can also cause disabling dyskinesias.

Staff

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  • Melina Bordone

    Visiting research fellow

    melina [dot] bordone [at] med [dot] lu [dot] se

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  • Abderahim Gaceb

    Research assistant

    abderahim [dot] gaceb [at] med [dot] lu [dot] se

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  • Ana-Elena Teleuca

    Visiting doctoral student

    ana-elena [dot] teleuca [at] med [dot] lu [dot] se

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