Leukocyte Migration
Visiting address: Sölvegatan 19, BMC D14, 221 84 Lund
Service point: 66
Description
Our research group is interested in how to understand how integrins are regulated and reused, since de-novo synthesis would not be economic to any given cell. We are in particular interested in the integrin called LFA-1, which is the major integrin used by T lymphocytes. We want to better understand how LFA-1 is intracellularly transported and reused in a migrating cell as well in the immunological synapse and how this is perturb in diseases like cancer and autoimmunity.