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Medical Structural Biology

Faculty of Medicine / Department of Experimental Medical Science

Visiting address: Sölvegatan 19, BMC C13, 221 84 Lund

Service point: 66

Medical Structural Biology's profile in Lund University Research portal

Description

The main objectives for Lindkvist laboratory are to make use of structural biology techniques, such as X-ray crystallography, and combine that with microscopy to reveal mechanisms of action in the metabolic systems in the human body. We have for many years been studying the role of bacterial toxins (superantigens) in the immune system, as well as the specificity of certain channels facilitating the transport of glucose and glycerol. More recent insights have generated an entirely new perspective suggesting that an altered microbiota can contribute to development of insulin resistance. But the molecular connection between altered microbiota and insulin resistance, and hence development of metabolic disorders, is still unclear. Yet, recently it was discovered that bacterial toxins (superantigens) cause rabbits to develop the hallmark symptoms of type 2 diabetes, including insulin resistance and glucose intolerance.

Coworkers

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  • Hannah Åbacka

    Doctoral student

    hannah [dot] abacka [at] med [dot] lu [dot] se