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Tumor microenvironment

Faculty of Medicine / Department of Clinical Sciences, Lund / Section I / Tumor microenvironment
Tumor microenvironment's profile in Lund University Research portal

Description

The focus of our studies is to understand how cancer cells communicate within their hostile microenvironment during tumor development. The ultimate goal is to identify novel biomarkers and more rational treatment strategies of the most aggressive, therapy resistant tumors. Based on previous findings we explore the hypothesis that transport vesicles (exosomes and endosomes) promote tumor aggressiveness and constitute therapeutic targets specifically related to typical features of the tumor microenvironment. We use advanced experimental models at the cellular level in conjunction with patient samples and clinical trials to unravel how cancer cells adapt to intrinsic stress factors, such as hypoxia and acidosis. Our concept of taking advantage of specific tumor microenvironment characteristics in combination with a unique strategy for the identification of cancer cell target proteins has potential to provide new treatment concepts and diagnostic tools to the benefit for cancer patients.

Staff

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  • Mattias Belting

    Project manager

    mattias [dot] belting [at] med [dot] lu [dot] se

  • Sarah Beyer

    Research project participant

    sarah [dot] beyer [at] med [dot] lu [dot] se

  • Axel Boukredine

    Research project participant

    axel [dot] boukredine [at] med [dot] lu [dot] se

  • Anna Bång-Rudenstam

    Research project participant

    anna [dot] bang-rudenstam [at] med [dot] lu [dot] se

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  • Maria C Johansson

    Research project participant

    maria_c [dot] johansson [at] med [dot] lu [dot] se

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  • Jiaxin Li

    Research project participant

    jiaxin [dot] li [at] med [dot] lu [dot] se

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  • Ann-Sofie Månsson

    Research project participant

    ann-sofie [dot] mansson [at] med [dot] lu [dot] se

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  • Hugo Talbot

    Research project participant

    hugo [dot] talbot [at] med [dot] lu [dot] se