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Functional Breast Cancer Genomics

Faculty of Medicine / Department of Clinical Sciences, Lund / Section I / Breast/ovarian cancer
Website: http://research.med.lu.se/helena-persson

Phone: +46 70 606 88 19

Visiting address: Medicon Village, Hus 404:B3 - Scheelevägen 2, 22381 Lund

Postal address: Medicon Village, Hus 404:B3 - Scheelevägen 2, 22381 Lund

Service point: 90

Functional Breast Cancer Genomics' profile in Lund University Research portal

Description

Future cancer care will use mutation analysis of tumour DNA as a tool to match each patient with the best possible treatment. To do this we must improve our understanding of the importance of different mutations. Today, analyses completely focus on mutations that are relatively easy to interpret, while so-called "silent" or synonymous mutations, which do not directly alter a protein, are filtered out. However, also synonymous mutations can be functional through effects on e.g. mRNA splicing or the speed of translation. We study synonymous mutations in breast cancers from several thousand Swedish women to investigate their effects on tumour behaviour with a combination of bioinformatic analyses and functional studies. Through this research we wish to demonstrate that also "silent" mutations are important so that more patients can receive targeted treatment. Hopefully, our work will also lead to identification of new therapeutical targets and a reevaluation of the standard analysis of sequencing data.

Staff

A

  • Juliane Albrecht

    Research project participant, Doctoral student

    juliane [dot] albrecht [at] med [dot] lu [dot] se

M

  • Mirjam Müller

    Doctoral student

    mirjam [dot] muller [at] med [dot] lu [dot] se

P

  • Helena Persson

    Project manager, Research team manager

    helena [dot] persson [at] med [dot] lu [dot] se