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Genetics and Diabetes

Faculty of Medicine / Department of Clinical Sciences, Malmö
Genetics and Diabetes' profile in Lund University Research portal

Description

Diabetes is a heterogeneous disease defined by elevated glucose levels. It is caused by genetic and environmental risk factors that combine to cause dysregulation of glucose metabolism through insulin resistance and/or insulin deficiency. We study all types of diabetes to understand how disease heterogeneity affects progression, response to treatment and risk of complications. To this end we use large population and cohort studies, e.g. the All New Diabetes In Scania (ANDIS) cohort, and biobanks of human tissues, to which we apply genetic and bioinformatic methods, focusing on large scale “omics”. The overall aim is to describe the genetic and phenotypic heterogeneity to personalize and improve diabetes treatment. Specifically, we aim to characterize novel subtypes of type 2 diabetes previously defined by our group. Another research aim is identification of genetic risk variants and parent-of-origin effects for diabetes-related traits, to identify novel therapeutic targets and elucidate underlying mechanism.

Staff

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  • Åsalinda Lethagen

    Physician, Research project participant

    asalinda [dot] lethagen [at] med [dot] lu [dot] se

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  • Dina Mansour Aly

    Visiting research fellow

    dina [dot] mansour_aly [at] med [dot] lu [dot] se

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  • Om Prakash

    Visiting research fellow

    om [dot] prakash [at] med [dot] lu [dot] se

  • Rashmi Prasad

    Researcher, Associate professor

    rashmi [dot] prasad [at] med [dot] lu [dot] se

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